Article

Metastasis-initiating osteosarcoma subpopulations establish paracrine interactions with both lung and tumor cells to create a metastatic niche

2024-06-10

Abstract excerpt

<h4>ABSTRACT</h4> Osteosarcoma is an aggressive and deadly bone tumor, primarily afflicting children, adolescents, and young adults. Poor outcomes for osteosarcoma patients are intricately linked with the development of lung metastasis. While lung metastasis is responsible for nearly all deaths caused by osteosarcoma, identification of biologically defined, metastasis-targeting therapies remains elusive because t...

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Literature Corpus work: 6acb3c16-e364-57d2-a49f-93c40d42aa10
DOI: 10.1101/2024.06.09.597967

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