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Article

Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing

8 Nov 2017

Abstract excerpt

Fibroblasts are primary cellular protagonists of wound healing. They also exhibit circadian timekeeping, which imparts an approximately 24-hour rhythm to their biological function. We interrogated the functional consequences of the cell-autonomous clockwork in fibroblasts using a proteome-wide screen for rhythmically expressed proteins. We observed temporal coordination of actin regulators that drives...

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PMID: 29118260
DOI: 10.1126/scitranslmed.aal2774

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