Article

MYC and Epithelial to Mesenchymal Transition (EMT) Independently Predict Circadian Rhythm Disruption in Lung Adenocarcinoma

2025-08-21

Abstract excerpt

The molecular circadian clock is known to be disrupted in lung adenocarcinoma, and its disruption is pro-tumorigenic in mouse models of this disease. However, the determinants of disruption of the molecular clock in human cancer are not clear. We hypothesized that derangement in expression of specific circadian clock genes or elevated MYC expression could correlate with circadian disruption in human tumors, and us...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ca808af8-0f53-556b-b351-2ca203671b02
DOI: 10.1101/2025.08.15.670530

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MYC and Epithelial to Mesenchymal Transition (EMT) Independently Predict Circadian Rhythm Disruption in Lung AdenocarcinomaDOI 10.1101/2025.08.15.670530Read

Evidence for widespread dysregulation of circadian clock progression in human cancerSemantic proximity Read

Widespread dysregulation of the circadian clock in human cancerSemantic proximity Read

Inferring circadian rhythm disruptions in cancer using phase differences between clock genesSemantic proximity Read

Circadian Rhythm Disruption Promotes Lung Tumorigenesis.Semantic proximity Read

The Cancer Clock Is (Not) Ticking: Links between Circadian Rhythms and CancerSemantic proximity Read

Circadian clock circuitry deconvolutes colorectal cancer and lung adenocarcinoma heterogeneity in a dynamic time-related frameworkSemantic proximity Read

Single‐cell transcriptomic analysis reveals circadian rhythm disruption associated with poor prognosis and drug‐resistance in lung adenocarcinomaSemantic proximity Read

Circadian Disruption Drives Extracellular Matrix Remodeling to Facilitate Pulmonary Metastatic ColonizationSemantic proximity Read

Circadian disruption does not alter tumorigenesis in a mouse model of lymphomaSemantic proximity Read

Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignanciesSemantic proximity Read

Subtype-specific circadian clock dysregulation modulates breast cancer biology, invasiveness, and prognosisSemantic proximity Read

The circadian clock is disrupted in pancreatic cancerSemantic proximity Read