Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of the Clock Component Bmal1 in Mice Promotes Cancer Metastasis through the PAI‐1‐TGF‐ β ‐myoCAF‐Dependent Mechanism

17 Jun 2023

Abstract excerpt

The circadian clock in animals and humans plays crucial roles in multiple physiological processes. Disruption of circadian homeostasis causes detrimental effects. Here, it is demonstrated that the disruption of the circadian rhythm by genetic deletion of mouse brain and muscle ARNT-like 1 (Bmal1) gene, coding for the key clock transcription factor, augments an exacerbated fibrotic phenotype in various tumors....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circadian rhythm and melatonin
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Spaceflight effects on biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37330661
DOI: 10.1002/advs.202301505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of the Clock Component Bmal1 in Mice Promotes Cancer Metastasis through the PAI‐1‐TGF‐ β ‐myoCAF‐Dependent MechanismPMID 37330661Read ↗

Circadian Disruption Drives Extracellular Matrix Remodeling to Facilitate Pulmonary Metastatic ColonizationSemantic proximity Read ↗

Major roles of the circadian clock in cancerSemantic proximity Read ↗

Circadian Rhythm Disruption Promotes Lung Tumorigenesis.Semantic proximity Read ↗

Regulation of transforming growth factor-beta1 (TGF-β1)-induced pro-fibrotic activities by circadian clock gene BMAL1Semantic proximity Read ↗

Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival.Semantic proximity Read ↗

Disrupted circadian clocks and altered tissue mechanics in primary human breast tumoursSemantic proximity Read ↗

Clock controls angiogenesisSemantic proximity Read ↗

Deficiency in core circadian protein Bmal1 is associated with a prothrombotic and vascular phenotype.Semantic proximity Read ↗

Plasminogen activator inhibitor-1 and the circadian clock in metabolic disorders.Semantic proximity Read ↗

Circadian protein BMAL1 promotes breast cancer cell invasion and metastasis by up-regulating matrix metalloproteinase9 expressionSemantic proximity Read ↗

Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulatorSemantic proximity Read ↗

Disruption of Bmal1 Impairs Blood–Brain Barrier Integrity via Pericyte DysfunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.