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Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization

2023-07-10

Abstract excerpt

<h4>Purpose: </h4> For patients with osteosarcoma, disease-related mortality most often results from lung metastasis—a phenomenon shared with many solid tumors. While established metastatic lesions behave aggressively, very few of the tumor cells that reach the lung will survive. By identifying mechanisms that facilitate survival of disseminated tumor cells, we can develop therapeutic strategies that prevent and t...

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Literature Corpus work
ae10803e-970e-53c7-8d78-a02c32d96c53
DOI
10.21203/rs.3.rs-3129411/v1
Open publication

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Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonizationDOI 10.21203/rs.3.rs-3129411/v1
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