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Genetically engineered mouse models of pancreatic adenocarcinoma

11 Feb 2013

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of human cancer for which there are no effective therapies. Deep sequencing of PDAC tumors has revealed the presence of a high number of mutations (>50) that affect at least a dozen key signaling pathways. This scenario highlights the urgent need to develop experimental models that faithfully reproduce the natural history of these human...

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PMID: 23506980
DOI: 10.1016/j.molonc.2013.02.002

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