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Genetically engineered mouse models of pancreatic cancer: unravelling tumour biology and progressing translational oncology

26 Aug 2011

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) remains a devastating disease despite tremendous scientific efforts. Numerous trials have failed to improve the outcome on this deadliest of all major cancers. Potential causes include a still insufficient understanding of key features of this cancer and imperfect preclinical models for identification of active agents and mechanisms of therapeutic responses and resistance....

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PMID: 21873467
DOI: 10.1136/gutjnl-2011-300756

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