Genetically Engineered Mouse Models of Pancreatic Cancer: The KPC Model (<i>LSL‐Kras^G12D/+;LSL‐Trp53^R172H/+;Pdx‐1‐Cre</i>), Its Variants, and Their Application in Immuno‐oncology Drug Discovery

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) ranks fourth among cancer-related deaths in the United States. For patients with unresectable disease, treatment options are limited and lack curative potential. Preclinical mouse models of PDAC that recapitulate the biology of human pancreatic cancer offer an opportunity for the rational development of novel treatment approaches that may improve patient outcomes. With the...

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