Article

Combinatorial tumor suppressor gene targeting immortalizes primary pancreatic ductal cells, resulting in temporal, deterministic structural patterns across the genome

2026-03-27

Abstract excerpt

<title>Abstract</title> <p>Pancreatic carcinoma develops from pre-cancerous lesions. Limited sensitivity of current imaging modalities and biomarkers challenges early detection. Findings from murine in vivo models revealed deterministic structural patterns following heterozygous TP53 alteration. Few pancreatic duct cell culture models exist to study such molecular concepts in the early stages of the disease proce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d99e1d4c-0c1f-57cd-803b-5e46312bdc41
DOI: 10.21203/rs.3.rs-9124723/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Combinatorial tumor suppressor gene targeting immortalizes primary pancreatic ductal cells, resulting in temporal, deterministic structural patterns across the genomeDOI 10.21203/rs.3.rs-9124723/v1Read

Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice.Semantic proximity Read

A pipeline for rapidly generating genetically engineered mouse models of pancreatic cancer using in <i>vivo</i> CRISPRCas9 mediated somatic recombinationSemantic proximity Read

A Genetically Engineered Human Organoid Model Reveals Distinct Genetic and Epigenetic Barriers of Lineage Plasticity in Early PDAC TransformationSemantic proximity Read

Whole Genomes Define Concordance of Matched Primary, Xenograft, and Organoid Models of Pancreas CancerSemantic proximity Read

Molecular mechanisms of RACK1-driven metastasis in pancreatic ductal adenocarcinoma revealed by single-cell RNA sequencingSemantic proximity Read

Integrative genomic identification of therapeutic targets for pancreatic cancerSemantic proximity Read

Genomic evolution of pancreatic cancer at single-cell resolution.Semantic proximity Read

CRISPR/Cas technologies in pancreatic cancer research and therapeutics: recent advances and future outlookSemantic proximity Read

Diversity Across the Pancreatic Ductal Adenocarcinoma Disease Spectrum Revealed by Network-Anchored Functional GenomicsSemantic proximity Read

Challenges in genomic analysis of model systems and primary tumors of pancreatic ductal adenocarcinomaSemantic proximity Read

Single-Cell Analysis Differentiates the Effects of p53 Mutation and p53 Loss on Cell Compositions of Oncogenic Kras-Driven Pancreatic Cancer.Semantic proximity Read

Reconstitution of human PDAC using primary cells reveals oncogenic transcriptomic features at tumor onsetSemantic proximity Read