Article
PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation.
Molecular cancer research : MCR - 2 Jan 2024
Chen Hongxia, Bai Yunpeng, Kobayashi Michihiro, Xiao Shiyu, Barajas Sergio, Cai Wenjie, Chen Sisi, Miao Jinmin, Nguele Meke Frederick, Yao Chonghua, Yang Yuxia, Strube Katherine, Satchivi Odelia, Sun Jianmin, Rönnstrand Lars, Croop James M, Boswell H Scott, Jia Yuzhi, Liu Huiping, Li Loretta S, Altman Jessica K, Eklund Elizabeth A, Sukhanova Madina, Ji Peng, Tong Wei, Band Hamid, Huang Danny T, Platanias Leonidas C, Zhang Zhong-Yin, Liu Yan
Abstract excerpt
Receptor tyrosine kinase KIT is frequently activated in acute myeloid leukemia (AML). While high PRL2 (PTP4A2) expression is correlated with activation of SCF/KIT signaling in AML, the underlying mechanisms are not fully understood. We discovered that inhibition of PRL2 significantly reduces the burden of oncogenic KIT-driven leukemia and extends leukemic mice survival. PRL2 enhances oncogenic KIT signaling in...
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