Article
The cbl oncogene: a novel substrate of protein tyrosine kinases.
Australian and New Zealand journal of medicine - 1 Dec 1995
Langdon W Y
Abstract excerpt
The cbl oncogene was first identified as part of a transforming retrovirus which arose in a mouse pre-B cell lymphoma. Its protein product, p120cbl, is cytoplasmic and has several distinctive domains including a highly basic region, a RING finger motif and a large proline-rich domain. A mutation to cbl in the 70Z/3 pre-B cell lymphoma produces an oncogenic protein which exhibits a marked enhancement of tyrosine...
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