Article
CBL mutation-related patterns of phosphorylation and sensitivity to tyrosine kinase inhibitors.
Leukemia - 1 Jul 2012
Makishima H, Sugimoto Y, Szpurka H, Clemente M J, Ng K P, Muramatsu H, O'Keefe C, Saunthararajah Y, Maciejewski J P
Abstract excerpt
Recurrent homozygous CBL-inactivating mutations in myeloid malignancies decrease ubiquitin ligase activity that inactivates SRC family kinases (SFK) and receptor tyrosine kinases (RTK). However, the most important SFK and RTK affected by these mutations, and hence, the most important therapeutic targets, have not been clearly characterized. We compared SFK and RTK pathway activity and inhibitors in acute myeloid...
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