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Article

Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene.

The Journal of biological chemistry - 3 Mar 2017

Nadeau Scott A, An Wei, Mohapatra Bhopal C, Mushtaq Insha, Bielecki Timothy A, Luan Haitao, Zutshi Neha, Ahmad Gulzar, Storck Matthew D, Sanada Masashi, Ogawa Seishi, Band Vimla, Band Hamid

Abstract excerpt

Mutations of the tyrosine kinase-directed ubiquitin ligase CBL cause myeloid leukemias, but the molecular determinants of the dominant leukemogenic activity of mutant CBL oncogenes are unclear. Here, we first define a gain-of-function attribute of the most common leukemia-associated CBL mutant, Y371H, by demonstrating its ability to increase proliferation of hematopoietic stem/progenitor cells (HSPCs) derived...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28082680
DOI: 10.1074/jbc.M116.772723
PMCID: PMC5339751

Genes

CBL
KIT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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