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Article

CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1.

Blood - 22 Apr 2021

Belizaire Roger, Koochaki Sebastian H J, Udeshi Namrata D, Vedder Alexis, Sun Lei, Svinkina Tanya, Hartigan Christina, McConkey Marie, Kovalcik Veronica, Bizuayehu Amanuel, Stanclift Caroline, Schenone Monica, Carr Steven A, Padron Eric, Ebert Benjamin L

Abstract excerpt

Casitas B-lineage lymphoma (CBL) encodes an E3 ubiquitin ligase and signaling adaptor that regulates receptor and nonreceptor tyrosine kinases. Recurrent CBL mutations occur in myeloid neoplasms, including 10% to 20% of chronic myelomonocytic leukemia (CMML) cases, and selectively disrupt the protein's E3 ubiquitin ligase activity. CBL mutations have been associated with poor prognosis, but the oncogenic...

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Identifiers

PMID: 33512474
DOI: 10.1182/blood.2020006528
PMCID: PMC8063090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1.PMID 33512474Read ↗

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