Article

The mechanism of IL-1β-mediated Piezo1 regulating chondrocyte autophagy and apoptosis through PI3K/AKT/mTOR signaling pathway

2023-01-04

Abstract excerpt

For the pathogenesis of osteoarthritis (OA), the classical view is that chondrocyte apoptosis is associated with and may cause age-related joint degeneration. Recent observations indicate that Piezo1, a mechanical stress channel expressed in articular cartilage, plays a key role in this process. We wanted to investigate whether other conditions activate the expression of Piezo1 in chondrocytes. Therefore, we simul...

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Literature Corpus work: ab67b447-b3e2-5276-97f4-cb2b9b9a9bbe
DOI: 10.21203/rs.3.rs-2413091/v1

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