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Endothelial restoration of CAD GWAS gene PLPP3 by nanomedicine suppresses YAP/TAZ activity and reduces atherosclerosis <i>in vivo</i>

2021-05-07

Abstract excerpt

Genome-wide association studies (GWAS) have suggested new molecular mechanisms in vascular cells driving atherosclerotic diseases such as coronary artery disease (CAD) and ischemic stroke (IS). Nevertheless, a major challenge to develop new therapeutic approaches is to spatiotemporally manipulate these GWAS-identified genes in specific vascular tissues in vivo . YAP (Yes-associated protein) and TAZ (transcription...

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Literature Corpus work
c46f58d3-be4a-5dcd-8cb8-c4d1be780cee
DOI
10.1101/2021.05.06.443006
Open publication

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Endothelial restoration of CAD GWAS gene PLPP3 by nanomedicine suppresses YAP/TAZ activity and reduces atherosclerosis <i>in vivo</i>DOI 10.1101/2021.05.06.443006
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