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Exploring the Multifactorial Regulation of PIEZO1 in Chondrocytes: Mechanisms and Implications

24 Jul 2025

Abstract excerpt

The mechanosensitive PIEZO1 ion channel plays a pivotal role in the regulation of chondrocyte function and is involved in various physiological and pathological processes, including cartilage degradation and osteoarthritis (OA). This review explores the regulatory mechanisms governing PIEZO1 activation and its interactions with mechanical stress, extracellular matrix (ECM) stiffness, inflammatory factors, and...

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PMID: 40765556
DOI: 10.7150/ijms.111082

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