Article

PIEZO1 force sensing controls global lipid homeostasis

2023-07-25

Abstract excerpt

<h4>ABSTRACT</h4> How cardiovascular activity beneficially regulates lipid homeostasis is unclear. Here we hypothesise a mechanism in which mechanical force sensed by PIEZO1 ion channels in endothelium links blood flow to lipid regulation. We engineered mice for conditional deletion of PIEZO1 in endothelium and determined consequences for lipid regulation. Prominent are upregulated expression of hepatic Cyp7a1 a...

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Literature Corpus work: ca4d1c4e-0996-5611-9c10-23a1ae363b5f
DOI: 10.1101/2023.07.23.550198

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