Article

Stimulation of cardiac fibroblast Piezo1 channels opposes myofibroblast differentiation and induces IL-6 secretion via Ca <sup>2+</sup> -mediated p38 MAP kinase activation

2019-04-10

Abstract excerpt

Piezo1 is a mechanosensitive cation channel with widespread physiological importance; however its role in the heart is poorly understood. Cardiac fibroblasts are responsible for preserving the structural integrity of the myocardium and play a key role in regulating its repair and remodeling following stress or injury. We investigated expression and function of Piezo1 in cultured human and mouse cardiac fibroblasts...

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Literature Corpus work: b35b2002-33e4-5e4e-93b0-a8ee934749e1
DOI: 10.1101/603456

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Stimulation of cardiac fibroblast Piezo1 channels opposes myofibroblast differentiation and induces IL-6 secretion via Ca <sup>2+</sup> -mediated p38 MAP kinase activationDOI 10.1101/603456Read

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