Article

Transition bias influences the evolution of antibiotic resistance in <i>Mycobacterium tuberculosis</i>

2018-09-20

Abstract excerpt

Transition bias, an overabundance of transitions relative to transversions, has been widely reported among studies of mutations spreading under relaxed selection. However, demonstrating the role of transition bias in adaptive evolution remains challenging. We addressed this challenge by analyzing adaptive antibiotic-resistance mutations in the major human pathogen Mycobacterium tuberculosis . We found strong evid...

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Literature Corpus work: 33bf8a47-a850-500f-8cde-8d7f721d9342
DOI: 10.1101/421651

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