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Article

Evolution and evolvability of rifampicin resistance across the bacterial tree of life.

Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2025

Bolourchi Negin, Brown Christopher R P, Letten Andrew D, Engelstädter Jan

Abstract excerpt

Predicting the ability of bacteria to develop antibiotic resistance is challenging, especially for the vast majority of species for which no experimental data are available. Here, we investigated the evolvability and intrinsic presence of rifampicin resistance across the bacterial tree of life. We compiled a comprehensive panel of known rifampicin resistance mutations, comprising 57 amino acid substitutions...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40737327
DOI: 10.1073/pnas.2424307122
PMCID: PMC12337354

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