Article

Dinucleotide codon mutations as a marker of diversifying selection in <i>M. tuberculosis</i>

2025-06-02

Abstract excerpt

The evolution of the human pathogen M. tuberculosis is shaped by various but interconnected processes of drug treatment pressure and host adaptation. We hypothesize that rarely accounted dinucleotide substitutions within a single codon, which allow for a broader range of amino acid substitutions than single nucleotide changes, are a significant aspect of diversifying selection. From the analysis of 43 studies, c...

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Literature Corpus work: bda6cc26-c436-5a9f-b1d7-d23e3ea1a205
DOI: 10.1101/2025.05.30.657033

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