Mutation bias alters the distribution of fitness effects of mutations.

Abstract excerpt

Mutation bias is an important factor determining the diversity of genetic variants available for selection. As adaptation proceeds and some beneficial mutations are fixed, new beneficial mutations become rare, limiting further adaptation. The depletion of beneficial mutations is especially stark within the mutational class favored by the existing mutation bias. Recent theoretical work predicts that this problem...

Topics

• Escherichia coli
• Genetic Fitness
• Mutation
• Selection, Genetic
• Models, Genetic
• Evolution, Molecular