Evidence for the Selective Basis of Transition-to-Transversion Substitution Bias in Two RNA Viruses.

Abstract excerpt

The substitution rates of transitions are higher than expected by chance relative to those of transversions. Many have argued that selection disfavors transversions, as nonsynonymous transversions are less likely to conserve biochemical properties of the original amino acid. Only recently has it become feasible to directly test this selective hypothesis by comparing the fitness effects of a large number of...

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