Article

MYC Dysregulates Mitotic Spindle Function Creating a Dependency on TPX2

2018-02-26

Abstract excerpt

The MYC oncogene promotes tumorigenesis in part by facilitating cell cycle entry thus driving cellular proliferation. Tumors that overexpress MYC frequently demonstrate aneuploidy, numerical chromosome alterations associated with highly aggressive cancers, rapid tumor evolution, and poor patient outcome. While the role of MYC in overcoming the G1/S checkpoint is well established, it remains poorly understood wheth...

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Literature Corpus work: 1a52b1f9-ddf6-5251-8380-87f0a79370ea
DOI: 10.1101/272336

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