Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tpx2 Controls Spindle Integrity, Genome Stability, and Tumor Development

21 Jan 2012

Abstract excerpt

Tpx2 is a microtubule-associated protein that activates the cell-cycle kinase Aurora A and regulates the mitotic spindle. Overexpression of Tpx2 is associated with the development of different human tumors and strongly correlates with chromosomal instability. By analyzing a conditional null mutation in the mouse Tpx2 gene, we show here that Tpx2 expression is essential for spindle function and chromosome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22266221
DOI: 10.1158/0008-5472.can-11-1971

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tpx2 Controls Spindle Integrity, Genome Stability, and Tumor DevelopmentPMID 22266221Read ↗

TPX2.Semantic proximity Read ↗

MYC Dysregulates Mitotic Spindle Function Creating a Dependency on TPX2Semantic proximity Read ↗

Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2Semantic proximity Read ↗

MYC Dysregulates Mitosis, Revealing Cancer VulnerabilitiesSemantic proximity Read ↗

Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells.Semantic proximity Read ↗

TPX2 Amplification-Driven Aberrant Mitosis in Long-Term Cultured Human Embryonic Stem CellsSemantic proximity Read ↗

Control of Aurora-A stability through interaction with TPX2Semantic proximity Read ↗

Targeted TPX2 increases chromosome missegregation and suppresses tumor cell growth in human prostate cancerSemantic proximity Read ↗

Regulation of Xenopus Aurora A activation by TPX2.Semantic proximity Read ↗

Anaphase-promoting complex/cyclosome controls the stability of TPX2 during mitotic exit.Semantic proximity Read ↗

The Tubulin Code in Mitosis and CancerSemantic proximity Read ↗

Ckap2 Regulates Aneuploidy, Cell Cycling, and Cell Death in a p53-Dependent MannerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.