Article

Replication fork remodeling proteins, Smc5/6 and Rtt107, promote palindrome-mediated genome instability

2026-05-01

Abstract excerpt

Palindromic sequences are a potent source of genomic instability that can lead to cancer and hereditary diseases in humans. Molecular evidence shows that palindrome instability results from the formation of secondary structures, such as hairpins and cruciforms, which are cleaved by structure-specific nucleases. However, the mechanisms underlying cruciform formation and cleavage at palindromic sequences in eukaryot...

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Literature Corpus work: 337d6c61-6bf6-5a30-b59c-4917d1bba4bd
DOI: 10.64898/2026.04.29.721645

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