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Article

Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination.

The Journal of cell biology - 30 Jun 2008

Banerjee Soma, Smith Stephanie, Oum Ji-Hyun, Liaw Hung-Jiun, Hwang Ji-Young, Sikdar Nilabja, Motegi Akira, Lee Sang Eun, Myung Kyungjae

Abstract excerpt

Gross chromosomal rearrangement (GCR) is a type of genomic instability associated with many cancers. In yeast, multiple pathways cooperate to suppress GCR. In a screen for genes that promote GCR, we identified MPH1, which encodes a 3'-5' DNA helicase. Overexpression of Mph1p in yeast results in decreased efficiency of homologous recombination (HR) as well as delayed Rad51p recruitment to double-strand breaks...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18591428
DOI: 10.1083/jcb.200711146
PMCID: PMC2442200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination.PMID 18591428Read ↗

Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase.Semantic proximity Read ↗

Genetic evidence for a role of Saccharomyces cerevisiae Mph1 in recombinational DNA repair under replicative stress.Semantic proximity Read ↗

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The Mph1 helicase can promote telomere uncapping and premature senescence in budding yeast.Semantic proximity Read ↗

Rad5-dependent DNA repair functions of the Saccharomyces cerevisiae FANCM protein homolog Mph1.Semantic proximity Read ↗

Mph1 requires mismatch repair-independent and -dependent functions of MutSalpha to regulate crossover formation during homologous recombination repair.Semantic proximity Read ↗

Budding yeast Mph1 promotes sister chromatid interactions by a mechanism involving strand invasion.Semantic proximity Read ↗

Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement.Semantic proximity Read ↗

SMARCAL1: a DNA repair protein recruited to double-strand breaks at stalled replication forks to promote genome stability through a homologous recombination pathwaySemantic proximity Read ↗

Suppression of spontaneous genome rearrangements in yeast DNA helicase mutants.Semantic proximity Read ↗

The Rad1-Rad10 complex promotes the production of gross chromosomal rearrangements from spontaneous DNA damage in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mrc1 is required for normal progression of replication forks throughout chromatin in S. cerevisiae.Semantic proximity Read ↗

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