Complex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases.

doi:10.1371/journal.pgen.1002979

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Article

Complex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases.

PLoS genetics - 1 Sept 2012

Pardo Benjamin, Aguilera Andrés

Abstract excerpt

DNA double-strand break (DSB) repair occurring in repeated DNA sequences often leads to the generation of chromosomal rearrangements. Homologous recombination normally ensures a faithful repair of DSBs through a mechanism that transfers the genetic information of an intact donor template to the broken molecule. When only one DSB end shares homology to the donor template, conventional gene conversion fails to...

Topics

Chromosome Aberrations
Chromosomes, Fungal
DNA Repair
DNA Replication
DNA, Fungal
DNA-Binding Proteins
Electrophoresis, Gel, Pulsed-Field
Endodeoxyribonucleases
Endonucleases
Gene Conversion
Genetic Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Holliday Junction Resolvases

Mutation

Recombination, Genetic

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Translocation, Genetic

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Identifiers

PMID: 23071463
DOI: 10.1371/journal.pgen.1002979
PMCID: PMC3459980

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