Article

Recognition and remodelling of nucleosomes and hexasomes by the human INO80 complex

2025-08-26

Abstract excerpt

The ATP-dependent INO80 chromatin remodeller slides and repositions nucleosomes to shape and maintain chromatin around gene regulatory elements and replication origins. Recent work uncovered capabilities of yeast and fungal INO80 to bind and slide hexasomes, but whether this is a universal feature is unknown. Here, we show that also human INO80 slides hexasomes as efficiently as H2A and H2A.Z nucleosomes. By deter...

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Literature Corpus work: 33701fb2-29cd-58e3-9ff7-f469ad28c184
DOI: 10.1101/2025.08.25.671740

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