Article
The essential histone variant H2A.Z regulates the equilibrium between different chromatin conformational states.
Nature structural biology - 1 Mar 2002
Fan Jun Y, Gordon Faye, Luger Karolin, Hansen Jeffrey C, Tremethick David John
Abstract excerpt
Explaining the determinants involved in regulating the equilibrium between different chromatin structural states is fundamental to understanding differential gene expression. Histone variant H2A.Z is essential to chromatin architecture in higher eukaryotes but its role has not yet been explained. We show here that H2A.Z facilitates the intramolecular folding of nucleosomal arrays while simultaneously inhibiting...
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