Article
Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding.
Nucleic acids research - 25 Sept 2020
Skrajna Aleksandra, Goldfarb Dennis, Kedziora Katarzyna M, Cousins Emily M, Grant Gavin D, Spangler Cathy J, Barbour Emily H, Yan Xiaokang, Hathaway Nathaniel A, Brown Nicholas G, Cook Jeanette G, Major Michael B, McGinty Robert K
Abstract excerpt
Nuclear proteins bind chromatin to execute and regulate genome-templated processes. While studies of individual nucleosome interactions have suggested that an acidic patch on the nucleosome disk may be a common site for recruitment to chromatin, the pervasiveness of acidic patch binding and whether other nucleosome binding hot-spots exist remain unclear. Here, we use nucleosome affinity proteomics with a library...
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