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Article

Stabilization and targeting of INO80 to replication forks by BAP1 during normal DNA synthesis.

Nature communications - 6 Oct 2014

Lee Han-Sae, Lee Shin-Ai, Hur Shin-Kyoung, Seo Jeong-Wook, Kwon Jongbum

Abstract excerpt

The INO80 chromatin-remodelling complex has been implicated in DNA replication during stress in yeast. However, its role in normal DNA replication and its underlying mechanisms remain unclear. Here, we show that INO80 binds to replication forks and promotes fork progression in human cells under unperturbed, normal conditions. We find that Ino80, which encodes the catalytic ATPase of INO80, is essential for mouse...

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Source

Identifiers

PMID: 25283999
DOI: 10.1038/ncomms6128

Genes

BAP1
INO80
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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