Article
Crystal structure of the overlapping dinucleosome composed of hexasome and octasome.
Science (New York, N.Y.) - 14 Apr 2017
Kato Daiki, Osakabe Akihisa, Arimura Yasuhiro, Mizukami Yuka, Horikoshi Naoki, Saikusa Kazumi, Akashi Satoko, Nishimura Yoshifumi, Park Sam-Yong, Nogami Jumpei, Maehara Kazumitsu, Ohkawa Yasuyuki, Matsumoto Atsushi, Kono Hidetoshi, Inoue Rintaro, Sugiyama Masaaki, Kurumizaka Hitoshi
Abstract excerpt
Nucleosomes are dynamic entities that are repositioned along DNA by chromatin remodeling processes. A nucleosome repositioned by the switch-sucrose nonfermentable (SWI/SNF) remodeler collides with a neighbor and forms the intermediate "overlapping dinucleosome." Here, we report the crystal structure of the overlapping dinucleosome, in which two nucleosomes are associated, at 3.14-angstrom resolution. In the...
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