Article

Understanding molecular mechanisms and predicting phenotypic effects of pathogenic tubulin mutations

2022-06-17

Abstract excerpt

Cells rely heavily on microtubules for several processes, including cell division and molecular trafficking. Mutations in the different tubulin-α and -β proteins that comprise microtubules have been associated with various diseases and are often dominant, sporadic and congenital. While the earliest reported tubulin mutations affect neurodevelopment, mutations are also associated with other disorders such as bleedi...

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Literature Corpus work: 7ac5e629-9535-5c8b-8afd-5ba82a9ef2ac
DOI: 10.1101/2022.06.16.496400

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