Resistance to antimitotic agents as genetic probes of microtubule structure and function.

Abstract excerpt

Much of our knowledge about microtubules has come from detailed morphological, biochemical, and cell biological studies. As more is learned about these organelles, questions regarding the in vivo regulation of their expression and function become increasingly important. Genetics provides an approach to address these more subtle questions in the living cell. Mammalian mutants with microtubule alterations have been...

Topics

• Animals
• Antineoplastic Agents
• DNA Probes
• Humans
• Microtubules
• Mutation