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Article

How Do Microtubule-Targeted Drugs Work? An Overview

1 Dec 2007

Abstract excerpt

The importance of microtubules in mitosis makes them a superb target for a group of highly successful, chemically diverse anticancer drugs. Knowledge of the mechanistic differences among the many drugs of this class is vital to understanding their tissue and cell specificity, the development of resistance, the design of novel improved drugs, optimal scheduling of treatment, and potential synergistic combinations....

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PMID: 18220533
DOI: 10.2174/156800907783220417

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