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Article

Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents.

Molecular oncology - 1 Jun 2018

Gerhards Nora M, Blomen Vincent A, Mutlu Merve, Nieuwenhuis Joppe, Howald Denise, Guyader Charlotte, Jonkers Jos, Brummelkamp Thijn R, Rottenberg Sven

Abstract excerpt

The absence of biomarkers to accurately predict anticancer therapy response remains a major obstacle in clinical oncology. We applied a genome-wide loss-of-function screening approach in human haploid cells to characterize genetic vulnerabilities to classical microtubule-targeting agents. Using docetaxel and vinorelbine, two well-established chemotherapeutic agents, we sought to identify genetic alterations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29689640
DOI: 10.1002/1878-0261.12307
PMCID: PMC5983209

Genes

HAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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