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Microtubule Targeting Agents in Disease: Classic Drugs, Novel Roles

12 Nov 2021

Abstract excerpt

Microtubule-targeting agents (MTAs) represent one of the most successful first-line therapies prescribed for cancer treatment. They interfere with microtubule (MT) dynamics by either stabilizing or destabilizing MTs, and in culture, they are believed to kill cells via apoptosis after eliciting mitotic arrest, among other mechanisms. This classical view of MTA therapies persisted for many years. However, the...

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PMID: 34830812
DOI: 10.3390/cancers13225650

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