Article

Spatially Resolved Panoramic in vivo CRISPR Screen via Perturb-DBiT

2025-05-08

Abstract excerpt

<title>Abstract</title> <p>Spatially resolved in vivo CRISPR screening integrates gene editing with spatial transcriptomics to examine how genetic perturbations alter gene expression within native tissue environments. However, current methods are limited to small perturbation panels and the detection of a narrow subset of protein-coding RNAs. We present Perturb-DBiT, a distinct and versatile approach for the sim...

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Literature Corpus work: 32e0dc54-e080-5399-a9d9-19fc1c5c7e95
DOI: 10.21203/rs.3.rs-6481967/v1

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