Article

In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma

2023-09-03

Abstract excerpt

Genetic perturbation screens with single cell readouts have enabled rich phenotyping of gene function and regulatory networks. These approaches have been challenging in vivo, especially in adult disease models such as cancer, which include mixtures of malignant and microenvironment cells. Glioblastoma (GBM) is a fatal cancer, and methods of systematically interrogating gene function and therapeutic targets in vi...

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Literature Corpus work: 1c083aa1-5a3f-54e9-b790-ab255ced5ada
DOI: 10.1101/2023.09.01.555831

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