Article

A Unifying Statistical Framework to Discover Disease Genes from GWAS

2022-04-29

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies (GWAS) identify genomic loci associated with complex traits, but it remains an open challenge to identify the genes underlying the association signals. Here, we extend the equations of statistical fine-mapping, to compute the probability that each gene in the human genome is targeted by a causal variant, given a particular trait. Our computations are enabled by se...

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Literature Corpus work: 32cc05a4-9f2f-5b52-b7af-4472f49bf9a5
DOI: 10.1101/2022.04.28.489887

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