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Article

Genetic fine-mapping from summary data using a nonlocal prior improves the detection of multiple causal variants.

Bioinformatics (Oxford, England) - 1 Jul 2023

Karhunen Ville, Launonen Ilkka, Järvelin Marjo-Riitta, Sebert Sylvain, Sillanpää Mikko J

Abstract excerpt

MOTIVATION: Genome-wide association studies (GWAS) have been successful in identifying genomic loci associated with complex traits. Genetic fine-mapping aims to detect independent causal variants from the GWAS-identified loci, adjusting for linkage disequilibrium patterns. RESULTS: We present "FiniMOM" (fine-mapping using a product inverse-moment prior), a novel Bayesian fine-mapping method for summarized genetic...

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Identifiers

PMID: 37348543
DOI: 10.1093/bioinformatics/btad396
PMCID: PMC10326304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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