Article

SparsePro: an efficient fine-mapping method integrating summary statistics and functional annotations

2021-10-06

Abstract excerpt

Identifying causal variants from genome-wide association studies (GWAS) is challenging due to widespread linkage disequilibrium (LD) and the possible existence of multiple causal variants in the same genomic locus. Functional annotations of the genome may help to prioritize variants that are biologically relevant and thus improve fine-mapping of GWAS results. Classical fine-mapping methods conducting an exhaustive...

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Literature Corpus work: f34be5bb-1485-5ee1-ae48-59c04c18f63b
DOI: 10.1101/2021.10.04.463133

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