Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

CAUSALdb2: an updated database for causal variants of complex traits.

Nucleic acids research - 6 Jan 2025

Wang Jianhua, Ouyang Liao, You Tianyi, Yang Nianling, Xu Xinran, Zhang Wenwen, Yang Hongxi, Yi Xianfu, Huang Dandan, Zhou Wenhao, Li Mulin Jun

Abstract excerpt

Unraveling the causal variants from genome wide association studies (GWASs) is pivotal for understanding genetic underpinnings of complex traits and diseases. Despite continuous efforts, tools to refine and prioritize GWAS signals need enhancement to address the direct causal implications of genetic variations. To overcome challenges related to statistical fine-mapping in identifying causal variants, CAUSALdb has...

Topics

Humans
Genome-Wide Association Study
Databases, Genetic
Polymorphism, Single Nucleotide
Multifactorial Inheritance
Linkage Disequilibrium
Bayes Theorem
Quantitative Trait Loci
Software
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 39558176
DOI: 10.1093/nar/gkae1096
PMCID: PMC11701604

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CAUSALdb2: an updated database for causal variants of complex traits.PMID 39558176Read ↗

CAUSALdb: a database for disease/trait causal variants identified using summary statistics of genome-wide association studies.Semantic proximity Read ↗

Functionally informed fine-mapping and polygenic localization of complex trait heritability.Semantic proximity Read ↗

Insights from complex trait fine-mapping across diverse populationsSemantic proximity Read ↗

An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci.Semantic proximity Read ↗

Genome-wide fine-mapping improves identification of causal variants.Semantic proximity Read ↗

Genome-wide fine-mapping improves identification of causal variantsSemantic proximity Read ↗

A Unifying Statistical Framework to Discover Disease Genes from GWASSemantic proximity Read ↗

GWASdb v2: an update database for human genetic variants identified by genome-wide association studies.Semantic proximity Read ↗

Genome-wide fine-mapping improves identification of causal variantsSemantic proximity Read ↗

Fine-mapping genetic associations.Semantic proximity Read ↗

Inferring genetic variant networks by leveraging pleiotropy shows trait relationships drive massive pleiotropy in GWASSemantic proximity Read ↗

PICS2: next-generation fine mapping via probabilistic identification of causal SNPs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.