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CAUSALdb2: an updated database for causal variants of complex traits.

Nucleic acids research - 6 Jan 2025

Wang Jianhua, Ouyang Liao, You Tianyi, Yang Nianling, Xu Xinran, Zhang Wenwen, Yang Hongxi, Yi Xianfu, Huang Dandan, Zhou Wenhao, Li Mulin Jun

Abstract excerpt

Unraveling the causal variants from genome wide association studies (GWASs) is pivotal for understanding genetic underpinnings of complex traits and diseases. Despite continuous efforts, tools to refine and prioritize GWAS signals need enhancement to address the direct causal implications of genetic variations. To overcome challenges related to statistical fine-mapping in identifying causal variants, CAUSALdb has...

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PMID: 39558176
DOI: 10.1093/nar/gkae1096
PMCID: PMC11701604

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