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Article

A refined Uni-vector prime editing system improves genome editing outcomes in mammalian cells.

Biotechnology journal - 1 Feb 2024

Huang Ching-Hui, Chiu Szu-Ying, Chou Yu-Chi, Wu Kou-Juey

Abstract excerpt

Prime editing is an advanced technology in CRISPR/Cas research with increasing numbers of improved methodologies. The original multi-vector method hampers the efficiency and precision of prime editing and also has inherent difficulty in generating homozygous mutations in mammalian cells. To overcome these technical issues, we developed a Uni-vector prime editing system, wherein the major components for prime...

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PMID: 38403398
DOI: 10.1002/biot.202300353

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