Article
Periodic stiffness encoded in genomes governs DNA mechanics
2026-06-23
Abstract excerpt
<title>Abstract</title> <p>DNA is not only a carrier of genetic information but also a physical polymer whose bending and looping underlie genome organization and gene regulation1–5. However, how DNA sequence encodes these mechanical properties has remained unclear. Here we show that rational design of DNA sequences based on bending stiffness enables predictable control of looping dynamics. We hypothesized that p...
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Identifiers and source
- Literature Corpus work
- 642cbfa8-33a8-5089-9e68-1d9b55af6376
- DOI
- 10.21203/rs.3.rs-9685896/v1