Article

<i>Tmed2</i> regulates Smoothened trafficking and Hedgehog signalling

2020-04-20

Abstract excerpt

Hedgehog (HH) signalling plays a key role in embryonic pattering and stem cell differentiation. Compounds that selectively bind Smoothened (SMO) can induce cell death in mouse embryonic stem cells (ESCs). Here we perform a genetic screen in haploid ESCs and discover that SMO inhibits a cell death pathway that resembles dissociation induced death of human ESCs and Anoikis. In mouse ESCs, SMO acts through a G-protei...

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Identifiers and source

Literature Corpus work: 323d53a5-a450-5817-990f-570baf421df9
DOI: 10.1101/2020.04.20.049957

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