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Article

Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development.

Scientific reports - 17 Feb 2016

Bhattacharyya Sohinee, Rainey Mark A, Arya Priyanka, Mohapatra Bhopal C, Mushtaq Insha, Dutta Samikshan, George Manju, Storck Matthew D, McComb Rodney D, Muirhead David, Todd Gordon L, Gould Karen, Datta Kaustubh, Gelineau-van Waes Janee, Band Vimla, Band Hamid

Abstract excerpt

Members of the four-member C-terminal EPS15-Homology Domain-containing (EHD) protein family play crucial roles in endocytic recycling of cell surface receptors from endosomes to the plasma membrane. In this study, we show that Ehd1 gene knockout in mice on a predominantly B6 background is embryonic lethal. Ehd1-null embryos die at mid-gestation with a failure to complete key developmental processes including...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26884322
DOI: 10.1038/srep20727
PMCID: PMC4756679

Genes

EHD1
SHH
EPS15
GLI3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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