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Article

Next-Generation Hedgehog/GLI Pathway Inhibitors for Cancer Therapy

15 Apr 2019

Abstract excerpt

The Hedgehog/Glioma-associated oncogene homolog (HH/GLI) signaling pathway regulates self-renewal of rare and highly malignant cancer stem cells (CSC), which have been shown to account for the initiation and maintenance of tumor growth as well as for drug resistance, metastatic spread and relapse. Efficacious therapeutic approaches targeting CSC pathways, such as HH/GLI signaling in combination with chemo,...

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PMID: 30991683
DOI: 10.3390/cancers11040538

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